Valid 02/2001 - 04/2001
Aldrich Chemical Co., Inc.
1001 West St. Paul
Milwaukee, WI 53233 USA
Tel: 414-273-3850
M A T E R I A L S A F E T Y D A T A S H E E T
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: D8418
NAME: DIMETHYL SULFOXIDE MOLECULAR
BIOLOGY REAGENT
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 67-68-5
MF: C2H6OS
EC NO: 200-664-3
SYNONYMS
A 10846 * DELTAN * DEMESO * DEMASORB * DEMAVET * DEMSODROX *
DERMASORB * DIMETHYL SULFOXIDE * DIMETHYL SULPHOXIDE * DIMEXIDE *
DIPIRARTRIL-TROPICO * DMS-70 * DMS-90 * DMSO * DOLICUR * DOMOSO *
DROMISOL * DURASORB * GAMASOL 90 * HYADUR * INFILTRINA * M 176 *
METHANE, SULFINYLBIS- * METHYLSULFINYLMETHANE * NSC-763 * RIMSO-50 *
SOMIPRONT * SQ 9453 * SULFINYLBIS(METHANE) * SYNTEXAN * TOPSYM *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
IRRITANT
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
COMBUSTIBLE LIQUID.
READILY ABSORBED THROUGH SKIN.
TARGET ORGAN(S):
EYES
SKIN
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
DO NOT BREATHE VAPOR.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
COMBUSTIBLE LIQUID.
METHYL SULFOXIDE (DMSO) UNDERGOES A VIOLENT EXOTHERMIC REACTION ON
MIXING WITH COPPER WOOL AND TRICHLOROACETIC ACID. ON MIXING WITH
POTASSIUM PERMANGANATE IT WILL FLASH INSTANTANEOUSLY. IT REACTS
VIOLENTLY WITH: ACID HALIDES, CYANURIC CHLORIDE, SILICON TETRACHLORIDE,
PHOSPHORUS TRICHLORIDE AND TRIOXIDE, THIONYL CHLORIDE, MAGNESIUM
PERCHLORATE, SILVER FLUORIDE, METHYL BROMIDE, IODINE PENTAFLUORIDE,
NITROGEN PERIODATE, DIBORANE, SODIUM HYDRIDE, PERCHLORIC AND PERIODIC
ACIDS. WHEN HEATED ABOVE ITS BOILING POINT METHYL SULFOXIDE DEGRADES
GIVING OFF FORMALDEHYDE, METHYL MERCAPTAN, AND SULFUR DIOXIDE.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
MECHANICAL EXHAUST REQUIRED.
SAFETY SHOWER AND EYE BATH.
WASH THOROUGHLY AFTER HANDLING.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH DMSO SOLUTIONS CONTAINING TOXIC MATERIALS OR
MATERIALS WITH UNKNOWN TOXICOLOGICAL PROPERTIES. DIMETHYL SULFOXIDE
IS READILY ABSORBED THROUGH SKIN AND MAY CARRY SUCH MATERIALS INTO
THE BODY.
AVOID PROLONGED OR REPEATED EXPOSURE.
KEEP TIGHTLY CLOSED.
KEEP AWAY FROM HEAT AND OPEN FLAME.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
PHYSICAL PROPERTIES
BOILING POINT: 189 C
MELTING POINT: 18.4 C
FLASHPOINT 188.6 F
87 C
EXPLOSION LIMITS IN AIR:
LOWER 42 %
VAPOR PRESSURE: 0.42 MMHG
SPECIFIC GRAVITY: 1.1 G
VAPOR DENSITY: 2.7 G/L
SWISS POISON CLASS: --
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
PROTECT FROM MOISTURE.
ACID CHLORIDES
PHOSPHORUS HALIDES
STRONG ACIDS
STRONG OXIDIZING AGENTS
STRONG REDUCING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
SULFUR OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
CAUSES SKIN IRRITATION.
READILY ABSORBED THROUGH SKIN.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF SWALLOWED.
AVOID CONTACT WITH DMSO SOLUTIONS CONTAINING TOXIC MATERIALS OR
MATERIALS WITH UNKNOWN TOXICOLOGICAL PROPERTIES. DIMETHYL SULFOXIDE
IS READILY ABSORBED THROUGH SKIN AND MAY CARRY SUCH MATERIALS INTO
THE BODY.
CHRONIC EFFECTS
TARGET ORGAN(S):
EYES
SKIN
RTECS #: PV6210000
METHYL SULFOXIDE
IRRITATION DATA
SKN-RBT 10 MG/24H OPEN MLD AIHAAP 23,95,1962
SKN-RBT 500 MG/24H MLD 85JCAE -,1044,1986
EYE-RBT 100 MG TXAPA9 39,129,1977
EYE-RBT 500 MG/24H MLD 85JCAE -,1044,1986
TOXICITY DATA
ORL-RAT LD50:14500 MG/KG TXAPA9 15,74,1969
SKN-RAT LD50:40 GM/KG ANYAA9 141,96,1967
IPR-RAT LD50:8200 MG/KG FCTOD7 22,665,1984
SCU-RAT LD50:12 GM/KG ARZNAD 14,1050,1964
IVN-RAT LD50:5360 MG/KG TXAPA9 7,104,1965
UNR-RAT LD50:1300 MG/KG NTIS** AD-A159-418
ORL-MUS LD50:7920 MG/KG CHTPBA 3,10,1968
SKN-MUS LD50:50 GM/KG ANYAA9 141,96,1967
IPR-MUS LD50:2500 MG/KG RPTOAN 35,300,1972
SCU-MUS LD50:14 GM/KG ANYAA9 141,96,1967
IVN-MUS LD50:3100 MG/KG TXAPA9 15,74,1969
UNR-MUS LD50:12 GM/KG USXXAM #4767763
ORL-DOG LD50:>10 GM/KG ANYAA9 141,96,1967
IVN-DOG LD50:2500 MG/KG CNCRA6 31,7,1963
ORL-CKN LD50:12 GM/KG JPPMAB 15,688,1963
ORL-MAM LD50:21400 MG/KG GISAAA 39(4),86,1974
ORL-BWD LD50:100 MG/KG TXAPA9 21,315,1972
TARGET ORGAN DATA
BEHAVIORAL (ALTERED SLEEP TIME)
LUNGS, THORAX OR RESPIRATION (DYSPNAE)
LUNGS, THORAX OR RESPIRATION (CYANOSIS)
GASTROINTESTINAL (NAUSEA OR VOMITING)
LIVER (JAUNDICE, OTHER OR UNCLASSIFIED)
BLOOD (OTHER CHANGES)
EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A CHEMICAL INCINERATOR
EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
IRRITANT
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
S 23
DO NOT BREATHE VAPOR.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
OEL-GERMANY: NO MAK ESTABLISHED, JAN1999
OEL-RUSSIA: STEL 20 MG/M3, JAN1993
OEL-SWEDEN: TWA 50 PPM (150 MG/M3), KTV 150 PPM (500 MG/M3), SKIN,
JAN1999
OEL-SWITZERLAND: MAK-W 50 PPM (160 MG/M3), SKIN, JAN1999
NOHS 1974: HZD 80564; NIS 11; TNF 476; NOS 25; TNE 22461
NOES 1983: HZD 80564; NIS 29; TNF 3507; NOS 40; TNE 44947; TFE 16837
EPA GENETOX PROGRAM 1988, POSITIVE: ASPERGILLUS-ANEUPLOIDY; S
CEREVISIAE GENE CONVERSION
EPA GENETOX PROGRAM 1988, NEGATIVE: SHE-CLONAL ASSAY; CELL
TRANSFORM.-MOUSE EMBRYO
EPA GENETOX PROGRAM 1988, NEGATIVE: CELL TRANSFORM.-RLV F344 RAT EMBRYO
EPA GENETOX PROGRAM 1988, NEGATIVE: D MELANOGASTER-WHOLE SEX CHROM.
LOSS; HOST-MEDIATED ASSAY
EPA GENETOX PROGRAM 1988, NEGATIVE: N CRASSA-ANEUPLOIDY; E COLI POLA
WITH S9
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST; IN
VITRO SCE-NONHUMAN
EPA GENETOX PROGRAM 1988, NEGATIVE: D MELANOGASTER SEX-LINKED LETHAL
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: ASPERGILLUS-RECOMBINATION;
CARCINOGENICITY-MOUSE/RAT
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER-RECIPROCAL
TRANSLOCATION
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: RODENT DOMINANT LETHAL; B
SUBTILIS REC ASSAY
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: E COLI POLA WITHOUT S9
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, OCTOBER 2000
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1999 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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